A single IRB refers to an IRB of Record (or IRB verification) selected on a study-by-study basis, in order to provide ethical verification to all sites participating in a multisite study. Streamlined, Multisite, Accelerated Resources for Trials IRB Reliance Platform or Smart IRB was designed to harmonize and streamline the IRB evaluation process for multi-site studies, while ensuring a high level of protection for research participants. Smart IRB is not an IRB, but a reliance master`s degree in which more than 580 participating institutions participate. The smart IRB-Master Reliance agreement replaces the need for an Individual Institutionalization Agreement (ILO). Northwestern University is a participating institution of Smart IRB and this method can be used to complete the trust process for a study conducted with another institution participating in Smart IRB. . . .